Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with Schistosoma japonicum.
Identifieur interne : 000C67 ( Main/Exploration ); précédent : 000C66; suivant : 000C68Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with Schistosoma japonicum.
Auteurs : Sandrine Cabantous [France] ; Xunya Hou [République populaire de Chine] ; Laurence Louis [France] ; Hongbin He [République populaire de Chine] ; Odette Mariani [France] ; Xavier Sastre [France] ; Martine Daujat-Chavanieu [France] ; Yuesheng Li [Australie] ; Alain Dessein [France]Source :
- International journal for parasitology [ 1879-0135 ] ; 2017.
Abstract
MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress.
DOI: 10.1016/j.ijpara.2017.05.007
PubMed: 28739251
Affiliations:
- Australie, France, République populaire de Chine
- Languedoc-Roussillon, Occitanie (région administrative), Provence-Alpes-Côte d'Azur, Île-de-France
- Marseille, Montpellier, Paris
- Université d'Aix-Marseille
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Electronic address: alain.dessein@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM), UMR906, GIMP, Labex ParaFrap, Aix-Marseille Université, 13005 Marseille</wicri:regionArea><wicri:noRegion>13005 Marseille</wicri:noRegion><placeName><settlement type="city">Marseille</settlement><region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j">International journal for parasitology</title><idno type="eISSN">1879-0135</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>République populaire de Chine</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Marseille</li><li>Montpellier</li><li>Paris</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Cabantous, Sandrine" sort="Cabantous, Sandrine" uniqKey="Cabantous S" first="Sandrine" last="Cabantous">Sandrine Cabantous</name></region><name sortKey="Daujat Chavanieu, Martine" sort="Daujat Chavanieu, Martine" uniqKey="Daujat Chavanieu M" first="Martine" last="Daujat-Chavanieu">Martine Daujat-Chavanieu</name><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><name sortKey="Louis, Laurence" sort="Louis, Laurence" uniqKey="Louis L" first="Laurence" last="Louis">Laurence Louis</name><name sortKey="Mariani, Odette" sort="Mariani, Odette" uniqKey="Mariani O" first="Odette" last="Mariani">Odette Mariani</name><name sortKey="Sastre, Xavier" sort="Sastre, Xavier" uniqKey="Sastre X" first="Xavier" last="Sastre">Xavier Sastre</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Hou, Xunya" sort="Hou, Xunya" uniqKey="Hou X" first="Xunya" last="Hou">Xunya Hou</name></noRegion><name sortKey="He, Hongbin" sort="He, Hongbin" uniqKey="He H" first="Hongbin" last="He">Hongbin He</name></country><country name="Australie"><noRegion><name sortKey="Li, Yuesheng" sort="Li, Yuesheng" uniqKey="Li Y" first="Yuesheng" last="Li">Yuesheng Li</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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